1. Starting Out Small
"Slow Ride" – Foghat
"Talk Dirty to Me" – Poison (PS3, Xbox 360 and PC versions feature Bret Michaels on vocals)
"Hit Me with Your Best Shot" – Pat Benatar
"Story of My Life" – Social Distortion
"Rock and Roll All Nite" – Kiss (Encore)
2. Your First Real Gig
"Mississippi Queen" – Mountain
"School's Out" – Alice Cooper
"Sunshine of Your Love" – Cream
"Barracuda" – Heart
Guitar Battle vs. Tom Morello (original composition)
"Bulls on Parade" – Rage Against the Machine (Encore played with Tom Morello)*
3. Making the Video
"When You Were Young" – The Killers
"Miss Murder" – AFI
"The Seeker" – The Who
"Lay Down" – Priestess
"Paint It Black" – The Rolling Stones (Encore - does not feature any alternate instrument and is not playable in co-op mode or offer any alternate instrument option in training mode)
4. European Invasion
"Paranoid" – Black Sabbath
"Anarchy in the U.K." – The Sex Pistols †
"Kool Thing" – Sonic Youth
"My Name Is Jonas" – Weezer
"Even Flow" – Pearl Jam (Encore)*
5. Bighouse Blues
"Holiday in Cambodia" – Dead Kennedys*
"Rock You Like a Hurricane" – Scorpions*
"Same Old Song and Dance" – Aerosmith
"La Grange" – ZZ Top
Guitar Battle vs. Slash (original composition)
"Welcome to the Jungle" – Guns N' Roses (Encore played with Slash)
6. The Hottest Band on Earth
"Black Magic Woman" – Santana[1]
"Cherub Rock" – The Smashing Pumpkins
"Black Sunshine" – White Zombie
"The Metal" – Tenacious D
"Pride and Joy" – Stevie Ray Vaughan (Encore)
7. Live in Japan
"Before I Forget" – Slipknot
"Stricken" – Disturbed
"3's & 7's" – Queens of the Stone Age
"Knights of Cydonia" – Muse
"Cult of Personality" – Living Colour (Encore)†
8. Battle for Your Soul
"Raining Blood" - Slayer
"Cliffs of Dover" – Eric Johnson
"The Number of the Beast" – Iron Maiden
"One" – Metallica
Guitar Battle vs. Lou (The Devil Went Down to Georgia – Steve Ouimette) (inspired by the Charlie Daniels Band)*
Once Co-op Career is complete, then all songs in the main setlist (except "Paint It Black" – "The Rolling Stones") will be unlocked for Co-op play
1. Getting a Band Together
"Barracuda" – Heart
"When You Were Young" – The Killers
"Bulls on Parade" – Rage Against the Machine*
"Slow Ride" – Foghat
"Sabotage" – Beastie Boys* (Encore)
2. We Just Wanna Be Famous
"School's Out" – Alice Cooper
"Kool Thing" – Sonic Youth
"Miss Murder" – AFI
"The Seeker" – The Who
"Reptilia" – The Strokes (Encore)
3. Overnight Success
"Paranoid" – Black Sabbath
"Welcome to the Jungle" – Guns N' Roses
"Anarchy in the U.K." – The Sex Pistols †
"Lay Down" – Priestess
"Suck My Kiss" – Red Hot Chili Peppers* (Encore)
4. Getting the Band Back Together
"Holiday in Cambodia" – Dead Kennedys*
"Black Magic Woman" – Santana
"Same Old Song and Dance" – Aerosmith
"Cherub Rock" – The Smashing Pumpkins
"Cities on Flame with Rock & Roll" – Blue Öyster Cult (Encore)
5. Jailhouse Rock
"My Name Is Jonas" – Weezer
"Black Sunshine" – White Zombie
"3's & 7's" – Queens of the Stone Age
"The Metal" – Tenacious D
"Helicopter" – Bloc Party (Encore)
6. Battle for Your Souls
"Knights of Cydonia" – Muse
"One" – Metallica
"The Number of the Beast" – Iron Maiden
"Cult of Personality" – Living Colour †
"Monsters" – Matchbook Romance (Encore)
"Avalancha" – Héroes del Silencio
"In the Belly of a Shark" – Gallows*
"Can't Be Saved" – Senses Fail
"Closer" – Lacuna Coil
"Don't Hold Back" – The Sleeping
"Down 'N Dirty" – LA Slum Lords
"F.C.P.R.E.M.I.X." – The Fall of Troy
"Generation Rock" – revolverheld*
"Go That Far" – Bret Michaels Band
"Hier Kommt Alex" – Die Toten Hosen
"I'm in the Band" – The Hellacopters
"Impulse" - An Endless Sporadic
"In Love" – Scouts of St. Sebastian
"Mauvais Garçon" – Naast
"Metal Heavy Lady" – Lions*
"Minus Celsius" – Backyard Babies
"My Curse" – Killswitch Engage
"Nothing for Me Here" – Dope
"Prayer of the Refugee" – Rise Against
"Radio Song" – Superbus
"Ruby" – Kaiser Chiefs
"She Bangs the Drums" – The Stone Roses
"Take This Life" – In Flames
"The Way It Ends" – Prototype
"Through the Fire and Flames" – DragonForce (unlocked by completing Career Mode)